Objective To investigate the effects of quadratus lumborum block on inflammatory response and postoperative intestinal function recovery in patients undergoing laparoscopic colorectal cancer surgery. Methods A total of 60 patients scheduled for laparoscopic colorectal cancer surgery were randomly divided into two groups：quadratus lumborum block combined with general anesthesia group（group QA，n = 30）and sole gen⁃ eral anesthesia group（group GA，n = 30）. The patients in group QA received bilateral quadratus lumborum block 30 minutes before induction of general anesthesia，and in group GA received simple general anesthesia，respectively. The concentration of serum TNF⁃α，IL⁃6 and IL⁃10 was measured at the following time points：5 minutes before anesthesia induction（T0），at the completion of pneumoperitoneum establishment（T1），6 h（T2）and 24 h（T3）after operation. The time of first exhaust and first walking time after operation，the incidence and degree of abdominal distension were recorded. Results Compared with the group GA，the levels of inflammatory factors at all time points in the group QA were significantly lower（P < 0.05）. The time of first exhaust in the group QA was signifi⁃ cantly shorter than that in the group GA（P < 0.05），and the first walking time after operation in the group QA was significantly longer than that in the group GA（P < 0.05）. The incidence of postoperative abdominal distension in the group QA was significantly lower than that in the group GA（P < 0.05）. Conclusions Quadratus lumborum block before operation can significantly reduce the inflammatory response and promote the rapid recovery of intestinal function in patients undergoing laparoscopic colorectal cancer surgery.